An update has been pushed to Raspberry Pi OS to flip the screen (rotate it by 180 degrees) for a better desktop viewing angle. This makes it upside-down in most stands/frames/cases, so you'll need to change a setting to flip it back.
To do this, open the config.txt file by using the following command in a terminal window:
sudo nano /boot/config.txt
Then add the line:
This will rotate both the LCD and the touch coordinates back to the right rotation.
Don't use the documented display_rotate, it performs a performance expensive rotation of the screen and does not rotate the touch input.
Customer tip! One of our customers couldn't get this to work until they removed the dtoverlay=vc4-fkms-v3d line from the config.txt file. You may want to try this if you're also having trouble (you can also just add a # in front of the line to tell your Pi to ignore it. Thanks for the tip Doug!